منابع مشابه
Use of Chimeric Fluorescent Proteins and FRET to Monitor Cellular Responses Imaging Microdomain Ca in Muscle Cells Optical Imaging of the Heart Examining Intracellular Organelle Function Using Fluorescent Probes Two-Photon Microscopy of Cells and Tissues
Fluorescence microscopy imaging has become one of the most useful techniques to assess the activity of individual cells, subcellular trafficking of signals to and between organelles, and to appreciate how organelle function is regulated. The past 2 decades have seen a tremendous advance in the rational design and development in the nature and selectivity of probes to serve as reporters of the i...
متن کاملUse of Chimeric Fluorescent Proteins and Fluorescence Resonance Energy Transfer to Monitor Cellular Responses Imaging Microdomain Ca in Muscle Cells Optical Imaging of the Heart Examining Intracellular Organelle Function Using Fluorescent Probes Two-Photon Microscopy of Cells and Tissue
Optical techniques have revolutionized the investigation of cardiac cellular physiology and advanced our understanding of basic mechanisms of electrical activity, calcium homeostasis, and metabolism. Although optical methods are widely accepted and have been at the forefront of scientific discoveries, they have been primarily applied at cellular and subcellular levels and considerably less to w...
متن کاملUse of Chimeric Fluorescent Proteins and Fluorescence Resonance Energy Transfer to Monitor Cellular Responses Imaging Microdomain Ca in Muscle Cells Optical Imaging of the Heart Examining Intracellular Organelle Function Using Fluorescent Probes Two-Photon Microscopy of Cells and Tissues
Ca ions passing through a single or a cluster of Ca -permeable channels create microscopic, short-lived Ca gradients that constitute the building blocks of cellular Ca signaling. Over the last decade, imaging microdomain Ca in muscle cells has unveiled the exquisite spatial and temporal architecture of intracellular Ca dynamics and has reshaped our understanding of Ca signaling mechanisms. Majo...
متن کاملDNA Damages on Blood Cells After Cardiac Magnetic Resonance Imaging
Introduction: Along with the increased use of cardiac imaging at clinics there is increased attention to the potential risks related to the methods used like magnetic resonance (MR) and it cannot be ruled out that MR can alter DNA structure. The aim of this review is to assess the impact of routine cardiac magnetic resonance (CMR) scanning on DNA damages in human T lymphocytes....
متن کاملMultimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes.
RATIONALE Cardiac myocyte contraction is caused by Ca(2+) binding to troponin C, which triggers the cross-bridge power stroke and myofilament sliding in sarcomeres. Synchronized Ca(2+) release causes whole cell contraction and is readily observable with current microscopy techniques. However, it is unknown whether localized Ca(2+) release, such as Ca(2+) sparks and waves, can cause local sarcom...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2004
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000125883.68447.a1